Wednesday, July 14, 2010

High-Powered Air Guns. No good reason.



Just look at this weapon. All the factors to make a gun nut cream himself. A pistol gripped, bi-poded, noise suppressed,  scoped, single action sniper rifle. Described by the merchant as "The Gunpower Storm. A high-performance take-down hunting rifle which also serves as an accurate target shooting gun".  Its all yours from www.guncity.co.nz for $1,999.00 including GST plus postage and packaging. No licence needed. Just flash your id and this killer is yours. This is an example of the high-powered air rifles that have received coverage due to the two recent homocides of the Don Wilkinson and Keith Kahi.


As you can see these are definitely not your average bb gun for shooting cans. I have commented on Gun-City before. This store, based in suburban Christchurch prides itself on being "New Zealand's Largest Gun Dealer". They import and sell by mail-order restricted military style semi-automatics to holders of endorsed licences, this I have only a little beef with, if a gun nut is willing to undergo the police vetting and individual registration required for the endorsement they are likely to be collectors who will use and store them safely. My BIG beef with them is their sale of military style weapons that have been modified just enough to be sold to persons with a standard licence (over 16, no police record) and are not required to be registered with the police. The weapons, like this modern AK-47 below, are from the factories as their military cousins, they have a shorter magazine and the pistol-grip (not removed as you can see) is incorporated into the stock those are the only modifications. Do you really want kids marching through high-schools with one of these? There is no good reason for owning these, if you want to hunt deer, buy a hunting rifle.


Criminal's will use what they can get. Hence the use of the traditional kiwi sawn-off .22 for pub, dairy and bank robberies.  These high-powered pre-charged air-rifles are just the next step up and look a hell of a lot more dangerous than, and are, a 50 year old rabbit gun stolen from a farm-house. The next level of escalation will be to these unregistered assault weapons.


The last time our gun laws were revised was post-Aramoana. I hope this week's two tragic episodes, the death of Keith Kahi in Auckland, the Christchurch slaying of Gage the police dog, will bring to gun-control to the forefront of political debate and the need to make changes to the availability of all firearms to the public. My big wish is for the sale of assault style weapons to be banned before too many are out and about in our communities. And prevent another Aramoana or heaven forbid a Columbine.  I wonder if the folk at Gun-City ever listen to the Mutton Birds song, a thing well made, this tells the story of a Christchurch gun dealer going about his work in the early 1990's. The collector down the line was D.M. Gray and this is his AK-47.



it's Wednesday
so I do the mail orders
there's nothing much
some oilskins and a 303
for a hunter over in Westland
and oh yeah
one of those AK-47s
for some collector down the line

-A thing well made: Don McGlashen


Peace,

Tony.

Tuesday, July 13, 2010

Antidepressants make shrimps see the light

Antidepressants make shrimps see the light

Maybe these shrimp or sea monkeys will make an interesting alternative model to determine antidepressant effects. It certainly has to be cheaper than using mice! Are there other advantages?

The standard measures in mice are related to despair behaviour which include tail-suspension and forced-swimming time. Both of these look at how long it takes for the animal to give up, sit and hang still or stick out their legs and float. Drugs or gene manipulations with antidepressant actions increase the time of these escape related movements. Other more sophisticated studies have looked at despair in relation to chronic-social defeat, where a little boy-mouse is exposed to a larger more aggressive man-mouse. This pattern of early life stress leads to the animal developing a phenotype similar to human depression. They stop enjoying their sweet treat biscuits (often froot-loops), groom less frequently and are less interested in hanging with other mice or use their cage toys.  These paradigms are challenging to set up and require continuous dosing for ~2weeks.

In that we understand so little about the mechanisms of action of antidepressants is it about time we go back to basic models? These shrimp move towards the light. Other folk have shown the microscopic worm C. elegans changes the way it moves his snout. What more can we learn from these simple, highly-tuned organisms, about drugs which are used to treat people experiencing their darkest times?